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KMID : 1038820160190040236
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Pediatric Gastroenterology, Hepatology & Nutrition
2016 Volume.19 No. 4 p.236 ~ p.242
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Clinical Features and Extraintestinal Manifestations of Crohn Disease in Children
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Lee Young-Ah
Chun Peter
Hwang Eun-Ha
Mun Sang-Wook
Lee Yeoun-Joo
Park Jae-Hong
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Abstract
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Purpose: The aim of this study was to investigate the clinical features and extraintestinal manifestations (EIMs) of Crohn disease (CD) in Korean pediatric patients.
Methods: The medical records of 73 children diagnosed with CD were retrospectively reviewed. Data regarding base-line demographic and clinical characteristics, including CD phenotype at diagnosis based on the Montreal classification, and clinical features and course of EIMs were investigated.
Results: Fifty-two (71.2%) of the patients were males. The mean age of the patients was 12.5 years. The mean follow-up period was 3.4 years. The disease location was ileal in 3 (4.1%) of the patients, colonic in 13 (17.8%), ileocolonic in 56 (76.7%). The clinical behavior was inflammatory in 62 (84.9%) of the patients, stricturing in 8 (11.0%), and penetrating in 3 (4.1%). Perianal abscesses or fistulas were found in 37 (50.7%) of the patients. EIMs observed during the study period were anal skin tag in 25 patients (34.2%), hypertransaminasemia in 20 (27.4%), peripheral arthritis in 2 (2.7%), erythema nodosum in 2 (2.7%), vulvitis in 1 (1.4%), uveitis in 1 (1.4%), and pulmonary thromboembolism in 1 (1.4%).
Conclusion: Perianal diseases and manifestations were present in more than half of Korean pediatric CD patients at diagnosis. Inspection of the anus should be mandatory in Korean children with suspicious CD, as perianal fistulas, abscesses, and anal skin tags may be the first clue to the diagnosis of CD.
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KEYWORD
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Crohn disease, Extraintestinal, Children
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